Role of 2D echo in neonates with perinatal asphyxia and its correlation with cardiac troponin T levels and creatine kinase MB

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Original Article

Author Details : Divya Mathur, Pradeep Kumar Gupta, Ajay Punj

Volume : 3, Issue : 2, Year : 2017

Article Page : 71-74

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Abstract

Objectives: To evaluate myocardial function in neonates with perinatal asphyxia by 2D Echo and cardiac Troponin T levels and creatine kinase MB.
Methods: 30 term babies with perinatal asphyxia were selected as cases. They were evaluated within 48 hours of birth using clinical echocardiography and cardiac enzymes i.e. Troponin -T and CK-MB levels.
Results: Incidence of cardiac dysfunction in neonates were reported and correlated with cardiac Troponin T levels and creatine phosphokinase MB- levels. In this study overall, 30% cases were reported with cardiogenic shock and cardiovascular dysfunction. 20% cases had clinical evidence of murmur. 16.6% cases had cardiac failure and 3.3% cases were asymptomatic. Cardiac enzymes were significantly increased in babies with perinatal asphyxia. Cardiac Troponin t levels ranges from 0.15- >=0.3ng/ml. CPK-MB levels ranged from 200±110 IU/L in this study. Tricuspid regurgitation seen in 6.7% cases. RV hypokinesia (67% cases) >LV hypokinesia (33.3%) cases. Incidence of cardiac changes and mortality increases with increasing levels of Troponin T.Mortality was seen in 2 out of 30 cases. The mean Troponin -T level in cases with cardiac dysfunction was 0.3ng/ml as compared to without cardiac dysfunction (<=0.1ng/ml). Cardiac Troponin T had higher sensitivity and specificity compared to CK-MB levels. Cardiac Troponin -t levels correlated well with severity and outcome in babies with perinatal asphyxia.
Conclusion: Echocardiography and cardiac enzymes i.e. cardiac troponin T levels and CK-MB levels correlates well with severity and outcome in perinatal asphyxia.

Keywords: Birth asphyxia, Cardiac troponin T, 2 D ECHO

How to cite : Mathur D, Gupta P K, Punj A, Role of 2D echo in neonates with perinatal asphyxia and its correlation with cardiac troponin T levels and creatine kinase MB. IP Int J Med Paediatr Oncol 2017;3(2):71-74

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