Acute myeloid leukemia/ transient abnormal myelopoeisis masquerading as sepsis in a neonate with down syndrome

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Case Report

Author Details : Naved Akter, Veenu Agarwal, Prachi Kumar

Volume : 3, Issue : 1, Year : 2017

Article Page : 42-44

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Abstract

A term 7 day old girl with phenotype of Down syndrome presented with irritability, poor feeding and respiratory distress for one day. She had echymotic patches on trunk and arm, moderate hepato-splenomegaly, swollen cyanosed cold right forearm. Neonatal sepsis was suspected but sepsis screen was negative. Peripheral blood smear revealed marked leucocytosis with 70% myeloblast cells, thrombocytopenia and normal erythrocyte count. Bone marrow had 48% myeloblasts. Differential diagnosis of transient abnormal myelopoiesis (with life threatening symptoms) and congenital leukemia were kept. We chose to report this case as it highlights the association between commonest chromosomal anomaly- Down syndrome and various hematological anomalies.

Keywords: Down Syndrome, Congenital Leukemia, Transient abnormal myelopoiesis

How to cite : Akter N, Agarwal V, Kumar P, Acute myeloid leukemia/ transient abnormal myelopoeisis masquerading as sepsis in a neonate with down syndrome. IP Int J Med Paediatr Oncol 2017;3(1):42-44

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